Current Issue : October-December Volume : 2020 Issue Number : 4 Articles : 5 Articles
Pantoprazole is the drug of proton pump inhibitor class. It is used for the treatment of stomach ulcers, short-term treatment of heartburn, gastroesophageal reflux disease. An ADR report related to a patient he developed vitamin B12 deficiency while being treated with pantoprazole. The patient, who had been treated with pantoprazole 20 mg BD for stomach upset, vomiting (G.I disturbance). After the treatment of 1 month the patient started weakness, pale skin, tingling in hands, dizziness and fatigue. The patient consulted his physician who is a gastroenterologist. After a thorough examination the physician asked to patient for blood tests which revealed that the Hb is normal but the amount of Vit. B12 present in the blood is less than the normal. It was confirmed that, after the use of pantoprazole Vit. B12 blood levels have decreased which lead to the sign and symptoms. This case report summarizes that on long term use of pantoprazole should be supported by supplemental therapy with Vit. B12....
In general, Women are prescribed more drugs than men and have an approximately 1.5 times higher risk of developing ADRs than men. ADR reported to the pharmacovigilance programme are analysed to explore new scientific information. Women are thought to be more at risk for ADRs. This study was aimed to analyse the cardiovascular drugs showing preponderance of adverse effects in female patients. The details of drugs selected for our study were filtered from Vigibase and the results were interpreted. Captopril, enalapril, losartan, valsartan, candesartam, aliskiren, lidocaine, bosentan, ambrisentan, macitentan, icantibant, verapamil, adenosine, propanolol, atenolol, metaprolol, labetalol amlodipine, nifedipene are the drugs which showed female preponderance of Adverse effects. Many drugs are known to produce more ADRs in female patients. Future studies are needed to explore pharmacokinetic and pharmacodynamic mechanisms causing more ADRs in females....
A Study on polypharmacy and potential drug – drug interactions in tertiary care hospital is beneficial for reducing the medication errors, adverse drug reactions and for improving the patients’ therapeutic outcomes. Drug interaction refers to modification of response to one drug by another drug when they are administered together; which can be severe, moderate or minor and also which is an important cause of adverse drug reactions (ADRs). A prospective interventional study was carried out for a period of six months from November 2017 to April 2018, in the inpatient departments of pediatric, oncology, surgery, general medicine, obstetrics and gynecology of two different tertiary care hospitals in Mysore District, with aim of evaluating potential drug interactions. The data are collected on patient’s demographic details, complaints, past medical history, current medications along with their ADRs. Potential drug –drug interactions (pDDIs) were identified using Medscape drug interaction checker. The data were analyzed using SPSS software. The Mean ± Standard deviation for age distribution found in our study was 35.69 ± 27.43. The total potential drug-drug interactions found in our study is 55.7%. Out of this Moderate pDDIs were most prevalent followed by Minor (14.81%) and Severe (9.42%).This study concluded that potential drug interactions are one of the major concerns that every patient under therapy with multiple drugs prescription suffer from which is a major challenge for ensuring drug safety along with effective treatment by systematic drug monitoring for potential interactions....
The epidemiology of drug-induced severe skin reactions accounts for 30% total of the world’s population. The Drugs such as NSAIDs, antibiotics, allopurinol, phenytoin, calcium channel blockers, cimetidine, quinidine, carbamazepine, gold, are mostly identified reported and are concerned with causing of drug-induced erythroderma which represents the inflammatory condition of the skin resulting with scaling and erythema which in turn affects more than 90% of the body surface. In the present case report, a male patient aged 77 years old with a weight of 52kg was admitted to department of DVI, Sai Siddartha Multi Speciality Hospital, Kakinada, Andhra Pradesh, India. Complaining about symptoms like itchy skin lesions over body since one month and describing his present illness as the rash developed over the trunk and later has been spread to other parts of his body. He further represented the past medical history such as he was diagnosed with pulmonary tuberculosis and was on antitubercular drug therapy with oral 300mg of Isoniazid. Based on the laboratory investigations and as well as based on the WHO-UMC causality ADR assessments information the case was undergone to a confirmatory diagnosis of drug-induced erythroderma which may be probably due to antitubercular drug usage....
Generic medicines are those where patent protection has expired and which may be produced by manufacturers other than the innovator company. The term ‘generic drug’ or ‘generic medicine’ is commonly understood, as defined by the World Health Organization (WHO), to mean a pharmaceutical product that is usually intended to be interchangeable with an innovator product, is manufactured without a license from the innovator company and is marketed after the expiry date of the patent or other exclusive rights. While the use of cheaper bioequivalent generic drugs over brand-name drugs has been widely discussed in literature, their market pricing and subsequent use is largely shaped by government policy-making as well as consumer and corporate decision-making. Problem faced may be by a Doctor or may be by Patient. This paper will discuss some of the issues around the generic drug in market....
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